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Stress conditions inducing cells more malleable than iPS cells

01-31-2014 11:18

A surprising method was reported last week in Nature (Obokata, H. et al. Nature 505, 641–647 (2014);
and Obokata, H. et al. Nature 505, 676–680 (2014).), to create "Stem cell" by putting cells in stress conditions, including a low pH. Obokata, one of the authors of the research, said this approach could make cells even more malleable than iPS cells and the process was faster and more efficiently. On average, 25% of the cells survive the stress and 30% of those convert to pluripotent cells — already a higher proportion than the roughly 1% conversion rate of iPS cells, which take several weeks to become pluripotent.
Shinya Yamanaka, who pioneered iPS cell research, says : "The findings are important to understand nuclear reprogramming" and "From a practical point of view toward clinical applications, I see this as a new approach to generate iPS-like cells."

For detailed information Please refer to:
http://www.nature.com/news/acid-bath-offers-easy-path-to-stem-cells-1.14600
http://www.nature.com/nature/journal/v505/n7485/full/nature12968.html
http://www.nature.com/nature/journal/v505/n7485/full/nature12969.html
 

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