Insignia vs. TCL: Who Wins the Battle for Budget Home Entertainment?

In today’s competitive smart TV market, choosing the right television can be a real challenge. With so many brands, features, and price points to consider, it’s easy to get overwhelmed. Two brands that often top the list for value-conscious buyers are Insignia and TCL. Insignia vs. TCL, This comparison will help you understand which TV might be the better fit for your needs by breaking down key areas like brand positioning, picture quality, features, pricing, and customer feedback.

Brand Overview and Positioning

Insignia is a Best Buy-exclusive brand (about Best Buy) designed for users who prioritize seamless streaming and affordability. With Amazon’s Fire TV platform deeply integrated, Insignia TVs offer quick access to major streaming services like Prime Video, Netflix, and Hulu without needing additional devices. The setup is user-friendly and ideal for those who want a plug-and-play experience.insignia TV BEAT BUY
TCL, on the other hand, is a global electronics giant known for its advanced display technology, including Mini LED innovation. TCL TVs are well-regarded for combining strong performance, innovative design, and a broad selection of screen sizes to suit both compact spaces and home theaters.

Picture Quality Comparison

Insignia TVs come equipped with 4K Ultra HD resolution and HDR support, including HDR10. These features provide sharp, detailed images with better contrast and richer colors. While Insignia does not lead in panel technology, its image quality is solid for typical home viewing, particularly for streaming HD and 4K content.
TCL TVs, especially models like the 98Q10K Pro, offer superior picture performance. They boast Mini LED panels, high peak brightness (up to 5500 nits), and thousands of local dimming zones (5184 on the Q10K Pro), which means significantly better black levels, color accuracy, and overall dynamic range. TCL excels in delivering cinematic picture quality, even in brightly lit rooms.

Smart Features and Usability

Insignia:

  • Fire TV Integration: Deep integration with Amazon Fire TV OS provides access to thousands of apps, a clean user interface, and regular updates.
  • Alexa Voice Control: Use voice commands for navigation, playback, or smart home control. It’s especially useful for users already in the Amazon ecosystem.
  • Streamlined Setup: The TV is easy to set up and navigate, making it suitable for all age groups.

TCL:insignia vs tcl

  • Versatile OS Options: TCL offers TVs with Roku TV, Google TV, and its own proprietary systems, giving users flexibility in UI preferences.
  • Smart Interactivity: TCL supports multi-device connectivity and casting from mobile devices.
  • Performance Power: More powerful CPUs and GPUs allow smoother multi-tasking and better gaming support.

Price and Value

Insignia stands out for its affordability. For example, a 32-inch Fire TV edition can be had for under $200, and 50-inch 4K models often cost less than $300. These TVs are perfect for secondary rooms, apartments, or users on a budget.
TCL TVs are competitively priced considering their technology. The 75T7L model, for example, offers a 75-inch screen, 2200-nit brightness, and 720 local dimming zones—features often seen in premium models—yet retails around $700. TCL balances premium specs with value, especially in the mid- and high-end segments.

Customer Feedback and Reputation

Insignia receives positive reviews for ease of use, Fire TV integration, and overall value. It’s often praised by users looking for a simple, effective smart TV without high costs. However, it’s not typically chosen for advanced picture performance or gaming.
TCL enjoys strong customer satisfaction, particularly for its Mini LED series. Users praise its rich blacks, vibrant colors, and premium-level performance at accessible prices. TCL also benefits from good after-sales support and frequent firmware updates.

Final Verdict: which TV is Better TCL or Insignia?

  • Choose Insignia if you prioritize affordability, seamless Amazon ecosystem integration, and a user-friendly interface for everyday streaming.
  • Choose TCL if you’re looking for top-tier display technology, immersive viewing experiences, and strong all-around performance.
Recommendation: For casual viewers, students, or budget-conscious buyers who mostly stream content via Prime Video or Netflix, Insignia offers great value. For home theater enthusiasts or users wanting superior image quality and more advanced features, TCL is the clear winner.
Before making a purchase, it’s always wise to check for seasonal discounts and bundle offers across platforms like Amazon, Best Buy, and Walmart.
… Read the rest
15/05/2025 by Home Appliances

Choosing the Perfect Curling Iron for Long Hair

bio ionic curling iron for long hair

Long, flowing hair cascades like a waterfall, embodying the beauty aspirations of countless women. To infuse romance and flair into your locks, a well-suited curling iron is non-negotiable.

Yet with the market flooded by curling irons of varying specs, how do you pick the right one to craft showstopping styles? Let’s dive into a detailed breakdown of the key factors.

bio ionic curling iron for long hair

Curling iron size: Determine the curling style of long hair ​

The size (diameter) of the curling iron is the key to shaping the curl of long hair. Different diameters correspond to completely different curling styles and suitable scenes. ​Explore premium options designed for lasting curls here: bioioniccurlingiron.com.

28-32mm curling iron:

This diameter creates natural, soft waves with fluffy, elegant bounce-a timeless choice for daily commutes or date nights. Wear it loose over your shoulders or half-up in a ponytail; either way, it adds a gentle, sweet charm that brings out layers and movement in your hair.
Best of all, these curls are low-maintenance: they hold their shape beautifully throughout the day, so you look polished from morning coffee to evening plans without constant touch-ups.

34-38mm curling iron:

Larger-diameter curling irons excel at crafting grand, laid-back styles for long hair. The loose curls they form fall in smooth, natural waves, mimicking the elegant drape of seaweed to create a carefree, effortless vibe.
These curls shine at evening events—think galas or cocktail parties. Paired with a sleek gown or chic cocktail dress, they add instant sophistication, elevating your entire look with a touch of old Hollywood glamour.

​

40mm and above curling irons:

super-large diameter curling irons can create dramatic waves, with loose and stretched curls, which can bring a unique retro charm or European and American fashion sense to long hair.

However, due to the large curls, the hair volume is required to be high. If the hair volume is too small, the curls may not be obvious enough, and the overall shape will appear thin. ​

Temperature regulation: taking into account both curls and hair health ​

Long hair itself is long, and the ends of the hair are relatively fragile, so the temperature regulation function of the curling iron is crucial.​

Wide range and precise temperature control

Choose a curling iron with a wide and precise temperature adjustment range. It is generally recommended that the temperature adjustment range be between 120℃ – 230℃, and it can be adjusted accurately to every 10℃.

For fine, soft and damaged long hair, the low temperature of 120-160℃ can meet the styling needs and reduce heat damage to the hair; while for thick, hard and healthy long hair, the temperature can be adjusted to 180-230℃ appropriately to ensure that the curls can be permanently fixed. ​

Intelligent temperature control system

Curling irons with intelligent temperature control function are the best choice for people with long hair. This type of curling iron can monitor the temperature in real time and automatically adjust to keep it constant, avoiding dry hair and split ends due to excessive temperature.

Even if used for a long time, it can better protect the health of long hair, so that the hair after curling is still soft and shiny. ​

Material performance: affecting the curling effect and hair quality​

The material of the curling iron is directly related to the curling effect and the health of the long hair.​

Heating element material

MCH metal ceramic heating element is a good choice for long hair curling irons. It heats up very quickly, usually reaching the preset temperature within 30 seconds, greatly saving styling time.

At the same time, its high heat conduction efficiency and uniform heat generation can allow long hair to be evenly heated during the curling process, avoiding local overheating damage, and making the curled hair lines smoother and more natural.

In contrast, although the PTC heating element is cheaper, its thermal stability and heating uniformity are slightly inferior, and it is not suitable for long hair styling with high requirements for curling effects. ​

Coating material

High-quality coating can effectively protect long hair.

Ceramic glaze coating can evenly distribute heat on the surface of the curling iron, reduce the pulling of hair, and make the curling process smoother.

Negative ion coating can release a large amount of negative ions, neutralize the static electricity generated by long hair during the curling process, close the hair scales, reduce hair frizz, and make the long hair after curling more smooth and shiny.

Other practical designs: Improve the styling experience of long hair ​

In addition to the core parameters, some detailed designs of the curling iron can also significantly improve the user experience.

Long barrel design

Long hair has more hair volume, and a longer barrel can curl more hair at one time, reducing the operation time and the number of repeated curling. It is recommended to choose a curling iron with a barrel length of more than 15cm, so that long hair styling can be completed more efficiently.

Anti-scalding design and safety function

A curling iron with an anti-scalding shell and a heat-insulating tip design can effectively avoid accidental burns during the curling process, especially when dealing with long hair, the operation space is larger, and such safety protection is more needed.

In addition, the automatic power-off function is also indispensable. If you forget to turn off the power, it can automatically turn off the power after a certain period of time to eliminate safety hazards. ​

Rotatable long power cord

During the process of styling long hair, you need to constantly change the angle and position. The long power cord that can rotate 360° (the length is recommended to be more than 2 meters) can make the operation more free and flexible, avoid the power cord from being entangled, and make the curling process smoother.​

Choosing the Perfect Curling Iron for Long Hair

Recommendations on curling iron selection for different long hair styles​

Romantic big wavy long hair

If you want to create romantic and charming big wavy long hair, a 32-38mm curling iron is the best choice. Start wrapping the curling iron from the middle of the hair and stay for 5-8 seconds to create a naturally drooping big wave. Paired with a flowing long skirt, it shows the feminine temperament. ​

Retro wool curl long hair

If you prefer retro-style wool curl long hair, a 22-28mm curling iron is more suitable. Divide the hair into thinner strands, tightly wrap the curling iron, and create fine small curls, which can create a retro and playful atmosphere. ​

Lazy and casual micro-curled long hair

For micro-curled long hair that pursues a lazy and casual feeling, use a 40mm or higher curling iron and gently pass the hair with a larger arc to create a loose and natural micro-curled effect, giving people a sense of casual fashion.​

When choosing a curling iron suitable for long hair, you need to consider factors such as size, temperature, material, and various practical designs. By combining your own hair quality and the hairstyle you want to create, you can easily make your long hair bloom with unique charm and create a variety of styles.… Read the rest

13/05/2025 by Fashion

Benefits of Yoga Pants For Women

why do women love to wear yoga pants

Having a wardrobe full of clothes you spend a lot of money on may sound like an extravagance. In the wholesale clothing world, there is always a niche for your taste in designer clothing for women, men, and children. And one of the popular and inexpensive clothes is yoga pants. Read this article to see what are the benefits of yoga pants women can get.

 

Why Do Women Love to Wear Yoga Pants?

why do women love to wear yoga pants

Women around the world wear yoga pants for all sorts of reasons. Sometimes it is because they want to do yoga wearing clothing that is extremely comfortable. Currently, yoga pants are hot options for girls and women.

Beyond that, there are women who take yoga just to stay in shape. Some women will wear a certain size and then take it two sizes smaller, thus making them feel “10 pounds lighter” when they do the poses. Does it sound like a great deal to you? Well, many people will rave about the benefits of getting into good shape just to feel more energetic the following year. Sounds familiar.

Another reason for wearing yoga pants is because some women like to feel attractive when they are out on the street. You need to realize that there are probably thousands of other people out there, just like you, who like to look appealing to wait in line at the store or in the checkout line. Why would they want to?

This looks irresistible mentality is an excellent reason to purchase yoga pants. Somehow, rubbing off the extra pounds makes you look a little “fabulous”, but that isn’t the only benefit. If you have done some form of exercise in the past, you will look better.

However, it is entirely possible that those people “joking around” you are actually enjoying their laughing because you look so good. Since, you will have more muscles, the bulge will look less obvious. You’ll be delighted to know that people notice little details, so now you can take it as an extra tip that you have worked on your body. In the end, it will pay off.

The majority of people think that they can’t get away with getting the “trouser look“. However, it was just a matter of time before trendy pants became popular. Just think of it as another one of those trends that will never go out of style. It is comfortable, and it is roomy and loose.

 

Should You Buy Yoga Pants?

If you are on a budget, all-in-one workout pants are no longer a luxury item. The majority of people have a tight budget these days. In the past, buying clothes outside of your budget was like drinking from a fire hose. However, with the advent of the internet, online shopping, and exciting new merchandising trends, it is possible to have a decent shopping budget.

Just like any other person, you probably have dreams and wishes. Those omnipresent entrepreneurs will definitely give you an answer. The best thing to do is to ask and get the answer from someone who is already doing it.

 … Read the rest

26/05/2022 by Fashion

How to Remove Oil Pastel Stains?

To use the very affordable and efficient method of removing oil pastel stains from your carpet, check the video:

When applying the pastel, you will need: A carpet pad. Be sure it is clean, undiluted, and exactly the size and shape you need. Otherwise, the pellet will get soggy and disgusting.

Also, the liquid may be too heavy to squeeze out. A cloth or a damp cotton ball will probably come in very handy on the carpet.

A carbon rod is a long trolley-style lifting device that can be run behind your vacuum cleaner.

Your home vacuum will pull in the wet carpet cleaner (just work it in a downward motion) then you move the carbon rod behind it.

Or, you can vacuum it one time with the wet one (especially when children are home). Although you can add a stain remover to your carpet, I think it is a bit dangerous.

And by the way, the problem with them is that they can neutralize the good qualities of the program Future artist wouldn’t be able to tell that the carpet is stained.

Yes, it definitely requires more involvement on the part of the decorator but it can be done. See the next paragraph for what to do with this situation

What to do in this situation:

It is almost impossible to eradicate the pastel oil stain all at one time.

First, group all of your carpet underhand towel duster your vacuum.

Then hit the carpet until it is soaked. Once it is up, use a dry duster around the carpet, but not all of it on the carpet. You want to sprinkle the oil stain remover on over the dry duster.

Have the kids do a little duster on the carpet they had for the musical chairs or other such purposes just to make sure it is taken out.

Why It Won’t Work?

Ideally, solvents should be used as a wetting agent. Solvents are available at most craft stores. The good thing about oil is that you don’t need the solvent to dissolve the oil.

Also, there is a product called “Fray Check” that used as a sealant and a UV ray ink. Make sure it is powdery and tacky. You want to use the powdery stuff.

Don’t use it in the UV tray as it will die in 10 seconds.

If at all possible, use the UV in the day you try to remove the oil.

You might note that after 15 minutes the pastel carpet looks significantly better, but after that you run the risk that it won’t adjust back to its normal state.

What to do in the other situations:

After trying the above suggestions, I would recommend the following:

Use a wet pro drafter brush so the carpet does not look worse at first. That is just a little extra face lift. If the ensemble has a groom’s cut, use a bit of filler (cotton balls, crumpled tissue paper) or a lullaby(where the consumer will absorb the fragrance) to finish the look.

A pro drafter brush is the best carpet sweeper available on the market. You get a little better coverage from most carpet cracks, and the classic six inch pore spacing gives the feel of a good oil-course sweeper.

And, it is not as skid-prone as the heavy-duty brush is for carpet.

The only thing is with the pro brush is that it does not have the neat fit look like the wax brush.

However, it covers the soggy areas better and it does not leave that balding effect like the paraffin. Layout is not the same as the wax lighter.… Read the rest

25/05/2022 by Healthcare

Is A Budget Rangefinder Worth Buying?

If you are considering purchasing a rangefinder for your bow hunting, you will want to do so. Even a budget rangefinder is worth the purchase. Rangefinders have been getting better and better. It’s got to a point where you can get a lot of valuable information with even some of the more inexpensive rangefinders on the marketplace. Below, we will be going over some of the benefits you should be able to get from buying one.

Benefits Of Buying A Budget Rangefinder:

cheap price laser rangefinder

1. You Can Achieve Greater Accuracy

More than anything, a budget rangefinder is necessary if you want to get the best possible accuracy with your shots. You need to have any kind of rangefinder if you want to be able to determine the right range to your target. Pretty much any expert will tell you that having access to any kind of rangefinder is essential no matter if you are a beginner or expert.

2. They Are Easy To Use

Any budget rangefinder you find on the marketplace is going to be pretty straightforward. Therefore, you should be able to find that it is very easy to use compared to what you would find with other products. Having something that is very easy to use is a big reason you should be investing in one even if it is a budget option and doesn’t offer much.

3. Better Than Ever

You will be able to find rangefinders on the market that are available for very affordable prices that have more features than ever before. Because you can find so many different options, you will be able to find one that is going to give you easy viewing and proper laser alignment dots which can sync with what you are doing.

4. They Don’t Cost Much

As mentioned, you are going to be able to find them for a very affordable price point. You won’t have to end up spending a lot of money on the purchase of your rangefinder. Because of this, they really should be considered a must purchase for anyone that is looking to improve their shots. They will give you the kind of information you need to make better shots and you don’t have to spend a fortune to do so. These rangefinders are getting increasingly affordable by the day.

get budget laser rangefinders

Overall, there are a lot of reasons you should be considering buying pocket machine even if you don’t have a lot of money to spend on one. Not only is it going to offer you a lot of benefits on its own, but it will allow you the opportunity to get better results out of your crossbow use. Having something that gives you accurate readings can really help you fine-tune your shots. You will be able to really get something that can add to your experience and help you whether you are right or left-handed. It is a must-have for anyone that is looking to have more information they can use to make better and more informed decisions when shooting.

You May Also Like:

How to Become A Better Hunter

10 Tips to Being A Better Deer Hunter

Steps You Can Take to Become A Better Hunter… Read the rest

13/08/2020 by Sports

Finding the Best Adjustable In Ground Basketball Hoops From Our Reviews

Spalding NBA Aluminum Trim Glass Backboard In-Ground Basketball System

in ground basketball hoops

With a solid standing position, this basketball hoop is firmly secured to the ground and it is worth owning and playing with. It has a cool ground sleeve to allow easy assembly and disassembly. Customers love this hoop because of its outstanding features such as an acrylic material design that is transparent and appealing. Its frame is designed with aluminum material that ensures longer durability. It has an all-weather net which equally enhances durability. It is weatherproof and does not stain. It has a U-Turn Lift system.

Features

  • Glass backboard is 60” to allow special rebounding and increased durability.
  • Uses a U-Turn lift system to allow for Spalding as its name suggest
  • Easy height adjustment of up to 10 feet. The player can play under the hoop.
  • The pole is square and made of steel to set it firm on the ground
  • The square pole that is made of steel
  • A 60-inch aluminum board style
  • 60 inch by 34-inch board size
  • 0.25-inch board frame made of tempered glass
  • Weighs 160 pounds
  • Made of glass

Pros

  1. Detachable handle
  2. Easy to adjust
  3. Durable
  4. Lightweight

Cons

Heavy

  1. Expensive

Lifetime Adjustable Basketball Hoop (54-inch Polycarbonate)

If you are looking for an appealing in-ground goal designed basketball hoop then this is the cool hoop for you. For those engaging in rugged and high-intensity play, this is worth it. It is designed with a 50-inch backboard that is resistant to shatter and breakage. It has a power lift adjustment to allow easy flexibility is up to 10 feet. It comes in exclusively cool black and clear colors.

best spalding basketball hoops

Features

  • An XL portable base
  • Power lift adjustment mechanisms
  • Slam it pro rim
  • Weighs 107 lbs.
  • It has a blow-molded background rim
  • Package weighs 92 pounds
  • Item weighs 87.4 pounds
  • Comes in clear and black colors
  • In-ground style item size: 54 inches backboard

Pros

  1. Durable
  2. Rigid and does not easily break apart
  3. It is portable
  4. One can adjust with one hand since it has a powerful life adjustment mechanism
  5. Suitable for high-intensity plays

Cons

  1. Mechanics of raising and lowering the rim can prove difficult in some cases

Kiddie Play Youth Basketball Hoop

If you want your kids to keep busy and exercised, then you have the right thing at hand. This model is specially designed for kids with high adjustability and portability. Your kids can either play with this basketball hoop indoors or outdoors. It is highly adjustable up to 8.7 feet; a perfectly designed size for kids to learn shooting tactics in basketball and develop their talents and hobbies. It is highly durable and can withstand harsh weather conditions.

kids use basketball hoops

Features

  • Adjustable up to 8.7’
  • Includes pump and basketball features
  • Covers indoor and outdoor usage
  • One can fill them with sand or water to ensure higher stability
  • Weighs 15 pounds
  • 15.3” hoop rim diameter
  • Measures 5.8” feet high up to 8.7” feet
  • Includes assembly tools and instructions

Pros

  1. Light
  2. Adjustable
  3. Durable
  4. Weather-resistant
  5. Indoor and outdoor services possible

Cons

  1. Limited to kids below 15 years

 … Read the rest

30/05/2020 by Sports

Takagi Tankless Water Heaters Worth Buying? Important Things to Consider

If you’re currently looking to upgrade your water heating system, you’ve likely come across many heaters produced by Takagi. The Takagi brand is a trusted name in the water heating sector, having a strong history of reliable and high-quality heaters. However, you might still have some questions regarding the brand before you consider making a purchase. There are many important things to consider before you buy Takagi tankless water heaters, especially when it comes to cost and efficiency.

takagi heaters for sale

The majority of Takagi tankless heaters cost slightly more than other common heaters available, but the price is justified. If you’re looking for a heater that is guaranteed to remain efficient and effective for years to come, going with the Takagi brand is a must. Although other brands may offer cheaper alternatives, you’ll end up paying more by going with heaters that require lots of repairs and maintenance throughout the years. Don’t forget that accumulated costs and fees for maintenance can easily overtake the initial price you paid for some systems. Takagi heaters are known particularly for their durability and longevity, giving you peace of mind.

takagi tankless water heater

Takagi tankless water heaters have a reputation for reliability that’s unmatched by all other heaters available in the same price range. Reputation is a key indicator to examine when judging whether a particular brand is worth considering for purchase or not. Reputations aren’t built overnight, so any brand that has either a bad or good reputation has consistently done something either wrong or right in the past months to years. Takagi heaters have slowly but surely formulated one of the strongest reputations for reliability throughout the years, making it an easy choice for those that want to go with a trusted name.

Manufacture and assembly of Takagi heaters are performed in Japan, a country known for having incredibly high standards for quality and efficiency. The vast majority of other brands in the sector manufacture their heaters in countries with much lower quality standards, making them more likely to exhibit faults and issues. One of the reasons why Takagi heaters cost slightly more than other common heaters is due to producing their products in Japan. However, when you consider the long-term implications of getting a better-built product, the slight price increase is justifiable.

Innovation forms the basis of many Takagi water heaters, with many new models exhibiting breakthrough features and functions. Most other manufacturers in the industry lazily rehash the same designs and models they’ve produced for years. Going with uninspired water heaters leads to lackluster results when implemented within your home. Takagi water heaters are renowned for continually pushing the envelope when it comes to formulating new mechanisms and new features that improve the effectiveness of water heating.

buying takagi heaters

Financing options available with many Takagi heating systems are flexible and generous, making it easy for you to make your first purchase. Many retailers understand the reliability of these heaters, so they make it incredibly easy for their customers to acquire them with simple payment solutions. Getting your hands on one of these heaters is entirely possible, simply talk to your local retailer about what options they have available for financing.

Resources:

https://www.assuredcomfort.com/news/why-is-my-water-heater-leaking-learn-4

https://heatersforlife.com/

 … Read the rest

10/04/2020 by Home Appliances

Buying New or Used Office Chair?

According to the recent study, an office chair should be changed after every five years, especially for kids. This ensures that the cushion is strong enough and maintains the required comfort to the user. You may also need to change your office chair so that your office is updated with the latest designs in the market.

You don’t have to go for a new chair always as you can get a used chair at a better price and enjoy the same features as a new one. But you should remember that a used chair might be slightly different from a new one.

With many sellers and different options in the market, buying an office chair is not a simple task. You need to have some tips to guide you through the process. This article will guide you through the essential tips that you should follow when buying new or used office chair.

best office chair for sciatica pain

So What Are the Tips to Follow?

1. Get ergonomic chair

An ergonomic chair is a chair that is made with adjustable parts so that it can suit a wide range of people. These type of chairs will support different people no matter their height, weight, and sitting posture. As stated earlier, an office chair will be used up to five years, and some may even last more. Within this period, several people may use the same chair, and this is the main reason why you need to choose an ergonomic chair when shopping.

2. Consider shape and material

As different people will have different taste and preference, office chairs come with various shapes and materials to meet the needs of everyone. With these varieties in the market, you should make sure you get exactly what you want. All you need is to consider your taste, and it will be easier to choose your perfect fit. Choose the best material that will last for a long time without wearing out. The shape will determine the comfort you get.

3. Adjustments

Get a chair that can be adjusted to different postures that you may need at different times of the day. You should pick the one that can be adjusted without the use of tools as this will save you time and make it easy to adjust the chair.

4. Look for a warranty

A warranty is what will guarantee you that the chair will serve you as expected. But you need to note that the warranty status for a used chair might be different from that of a new one. However, all of them should have a warranty to cover you from specified defects.

5. Check on quality and price

Price and quality are two different things and this why the price will never guarantee you quality. You need to get a high-quality chair at the best price. Concentrate more on the quality and the features that you want and not the price. Check the price from various sellers to ensure you get the chair at the best price.

Conclusion

Buying new or used office chair can be overwhelming, but with the above tips, it should be an easy task. Find best office chairs at bestratedofficechair.com.… Read the rest

09/08/2019 by Office Supplies

Fat Grizzly Bears May Help Scientists to Find Diabetes Drugs

Every fall, grizzly bears pack on the pounds in preparation for their winter hibernation. In humans, such extreme weight gain would likely lead to diabetes or other metabolic diseases, but the bears manage to stay healthy year after year. Their ability to remain diabetes-free, researchers have now discovered, can be chalked up to the shutting down of a protein found in fat cells. The discovery could lead to new diabetes drugs that turn off the same pathway in humans.

As people gain weight, fat, liver, and muscle cells typically become less sensitive to the hormone insulin—which normally helps control blood sugar levels—and insulin levels rise. In turn, that increased insulin prevents the breakdown of fat cells, causing a vicious cycle that can lead to full-blown insulin resistance or diabetes.

Developing new diabetes drugs has been hampered by the fact that findings from many mouse models of diabetes have not translated to humans. So Kevin Corbit, a senior scientist at Thousand Oaks, California–based drug company Amgen, decided to start looking at obesity and metabolic disease in other animals. “When I was thinking about things that are quite fat, one of the first things I thought of was bears, and what they do to prepare to go into hibernation,” he says. “But of course you don’t see bears running around with diabetes and heart disease.”

Corbit and scientists at the Washington State University Bear Center in Pullman measured blood sugar levels, insulin levels, body weight, and other markers of the metabolism in six captive grizzly bears before, during, and after hibernation—in October, January, and May. Surprisingly, even as each bear gained more than a hundred pounds in the fall, their cells remained sensitive to insulin, and their insulin and blood sugar levels stayed constant. In people, such an immense weight gain would likely cause insulin resistance. It wasn’t until well after they’d begun hibernating that bears experienced a temporary, seasonal episode of insulin resistance, but even that was completely reversed come springtime. “This type of physiology had never been described before and was completely opposite what’s seen in humans,” Corbit says.

When he and his collaborators analyzed levels of more molecules in the bears’ blood, liver, and fat cells, they found out what was controlling the insulin sensitivity and resistance independently from weight gain or loss: a protein called PTEN. In the fall, the bears have switched-off versions of PTEN present in their fat cells, Corbit’s team reports today in Cell Metabolism. As a result, the cells continue responding to insulin—and the signals to store sugar—even as the bears gain weight. For bears, the shutdown protein helps maximize sugar storage in their bodies for the long winter ahead.

The finding could also help humans, Corbit says. Because shutting off PTEN helps obese bears maintain insulin sensitivity, turning off the pathway in overweight people could prevent or treat diabetes, he suggests. Interestingly, he points out, a previous study found that people missing one gene for PTEN production are less likely to develop the metabolic or cardiovascular disease even as they gain weight. Those people do develop other diseases, including cancer, but Corbit suspects that’s because the PTEN levels are diminished body-wide. If scientists could turn it off only in fat cells—as bears do—these side effects might be diminished.

Metabolic disease specialist Abhimanyu Garg of the University of Texas Southwestern Medical Center in Dallas says that more evidence is needed to support any link between the bear finding and human diabetes. And you’d have to be careful with a drug that turns off PTEN, even if it’s only in fat cells, he says. Even if it could treat diabetes, it might also cause increased weight gain. After all, it helps bears store up their winter fat, Garg notes. “You might create a situation where patients are metabolically healthy but you’re trading that for joint problems and back problems and arthritis.”… Read the rest

29/07/2019 by Science

Science and Education

Science teaching is very important to people, especially to kids. Let's see how they are livening up science teaching in Japan.